A patient is suspected of having HS. However, there appear to be

[wrbasek0]

A patient is suspected of having HS. However, there appear to be <1 spherocytes on the peripheral blood smear, and the osmotic fragility test is normal. What test could be performed to increase the sensitivity of testing for HS?
 
  a. Incubated osmotic fragility test
  b. Immunophenotyping for CD55 and CD59
  c. Sucrose hemolysis test
  d. Ham test

Question 2

Mary, a 7-year-old, was admitted to the hospital after experiencing severe anemia following a respiratory infection. Her father has a history of RBC membrane abnormality and recently underwent a splenectomy to help alleviate the problem.
 
  Upon examination, it was revealed that Mary had hepatosplenomegaly and slight bruising on her forearms. A CBC was ordered, with the following results:
  HGB 9.0 g/dL
  HCT 24
  WBC 11  109/L
  RBC 3.8  1012/L
  MCV 102 fl
  MCH 25 pg
  MCHC 40
  PLT 275  109/L
  Peripheral smear: moderate macrocytes and stomatocytes
 
  Which of the following is most consistent with a presumptive diagnosis in this case?
  a. PNH
  b. HS
  c. DHS
  d. HE

[jlaineee]

Answer to Question 1

Correct Answer: A

Answer to Question 2

Correct Answer: B

[wrbasek0]

Excellent

[lindahyatt42]

Gracias!