Answer to Question 1
A negative symptom of schizophrenia is the absence of something that should be present in a
person but is not present. Negative symptoms might include:
Flat or blunted affect
Poverty of thought
Lack of motivation
Social withdrawal
Poor grooming
Anhedonia (inability to experience pleasure)
A positive symptom of schizophrenia is the presence of something that is not normally present,
such as:
Hallucinations
Delusions
Disorganized speech (associative looseness)
Bizarre behavior
a. Thought broadcasting:Belief that thoughts can be heard by others
b. Thought insertion:Belief that others' thoughts are being inserted or substituted into one's brain or
conversation
c. Grandeur:Belief about grand or exaggerated accomplishments; belief that one is very important
or has great power
d. Ideas of reference:Belief that events are related to one when they are not; giving great personal
significance to a trivial event
e. Persecution:Belief that one is being singled out by others for harmful reasons
f. Somatic delusions:Belief that one's body is changing in an unusual way
Preoccupation with one or more delusions: He is being persecuted, They have contaminated my
food, They are watching me.
Frequent auditory hallucinations: They told me not to cooperate.
Other factors or conditions can cause psychotic symptoms that are common with schizophrenia.
Drug use, certain medical or neurologic conditions, and alcohol withdrawal may cause psychosis.
It is common for people with schizophrenia to experience deterioration in their level of functioning
for up to a year before developing frank psychotic symptoms.
Family history: medical, neurologic, psychiatric
Mental status examination
Physical examination
Blood and urine drug screen; blood alcohol level
Complete blood count
Complete metabolic panel
Urinalysis
Protect him from harm to self and others; create a supportive, structured environment
Engage in supportive and directive communications
Establish a relationship with the patient in which he feels safe
Perform acute symptom stabilizationpsycho pharmacologic treatment
Answer to Question 2
Answers: a, b, d
Side effects are dose-related and are seldom noted if lithium levels are within normal limits.
Answers: a, d, e
Symptoms of early lithium toxicity include vomiting, diarrhea, lethargy, slurred speech, muscle
weakness, and fine hand tremor. As lithium levels rise above 2.0 mEq/L, coarse hand tremor,
persistent gastrointestinal upset, mental confusion, incoordination, and sedation may occur. Acute
toxicity may result in seizures, circulatory failure, pulmonary complications, and death
Maintenance blood levels for lithium should range from 0.4 to 1.3 mEq/L. Her level is within normal limits.
Thyroid function testsHypothyroidism is a risk of long-term lithium therapy.
Creatinine and blood urea nitrogen (BUN)Impairment of renal function is a risk of long-term
lithium therapy.
Sodium levelsDehydration can contribute to lithium toxicity.
Maintain adequate hydration at all times, but especially when perspiring heavily or losing fluids as
a result of vomiting or diarrhea.
Know the symptoms of toxicity. Hold the next dose of lithium, and notify your physician
immediately if symptoms of toxicity occur.
Certain antiseizure medications are often used to treat bipolar disorder. These include valproate
(Depakote), carbamazepine (Tegretol), and lamotrigine (Lamictal). Both valproate and
carbamazepine require blood level monitoring. Valproate requires monitoring of liver function and
platelet levels. Carbamazepine requires routine monitoring of the complete blood count, platelets,
and liver function study results.
Two of the atypical antipsychotics, risperidone (Risperdal) and olanzapine (Zyprexa), have been
used to treat bipolar disorder.
Answer: b
Avoid stressful situations.
Maintain a regular schedule for sleep and exercise.
Eat a healthy diet.
Avoid intake of caffeine, alcohol, drugs of abuse, and over-the-counter drugs; these might cause a
relapse, even in small amounts.
Take medications consistently, the same time every day.
Keep the appointments for group or individual psychotherapy support sessions.