The first step in the genomic assessment of a patient is ...

[Charlie]

The first step in the genomic assessment of a patient is obtaining information regarding:
 
  A. Family history
  B. Environmental exposures
  C. Lifestyle and behaviors
  D. Current medications

Question 2

Which of the following clinical reasoning tools is defined as evidence-based resource based on mathematical modeling to express the likelihood of a condition in select situations, settings, and/or patients?
 
  A. Clinical practice guideline
  B. Clinical decision rule
  C. Clinical algorithm
  D. Clinical recommendation

[ong527]

Answer to Question 1

ANS: A
A critical first step in genomic assessment, including assessment of risk, is the use of family history. Family history is considered the first genetic screen (Berry & Shooner 2004) and is a critical component of care because it reflects shared genetic susceptibilities, shared environment, and common behaviors (Yoon, Scheuner, & Khoury 2003).

Answer to Question 2

ANS: B
Clinical decision (or prediction) rules provide another support for clinical reasoning. Clinical decision rules are evidence-based resources that provide probabilistic statements regarding the likelihood that a condition exists if certain variables are met with regard to the prognosis of patients with specific findings. Decision rules use mathematical models and are specific to certain situations, settings, and/or patient characteristics.