On barium enema, colon cancer may appear as an apple core (a ...

[gbarreiro]

On barium enema, colon cancer may appear as an apple core (a constricting lesion) or a mass with a filling defect. What is a filling defect?
 
  What will be an ideal response?

Question 2

Why are aromatase inhibitors used in postmenopausal women to reduce estrogen levels? (hint: What is the source of estrogen in women with nonfunctioning or surgically removed ovaries?)
 
  What will be an ideal response?

[Hikerman221]

Answer to Question 1

An anatomical change that prevents contrast material from filling (flowing into and outlining) an anatomical space.

Answer to Question 2

The main source of estrogen in postmenopausal females is from the conversion of testosterone to estrogen. Postmenopausal women continue to produce testosterone in the adrenal glands. Testosterone is converted to estrogen by aromatase. Estrogen produced from the adrenal glands by way of testosterone conversion can be controlled by inhibiting aromatase (using aromatase inhibitors).

[gbarreiro]

Thanks for the timely response, appreciate it

[Mochi]

Wow, this really help