Which is most descriptive of the pathophysiology of leukemia? ...

[lb_gilbert]

Which is most descriptive of the pathophysiology of leukemia?
 
  a. Increased blood viscosity occurs.
  b. Thrombocytopenia (excessive destruction of platelets) occurs.
  c. Unrestricted proliferation of immature white blood cells (WBCs) occurs.
  d. First stage of coagulation process is abnormally stimulated.

Question 2

In which of the conditions are all the formed elements of the blood simultaneously depressed?
 
  a. Aplastic anemia
  b. Sickle cell anemia
  c. Thalassemia major
  d. Iron deficiency anemia

[fur]

Answer to Question 1

ANS: C
Leukemia is a group of malignant disorders of the bone marrow and lymphatic system. It is defined as an unrestricted proliferation of immature WBCs in the blood-forming tissues of the body. Increased blood viscosity may occur secondary to the increased number of WBCs. Thrombocytopenia may occur secondary to the overproduction of WBCs in the bone marrow. The coagulation process is unaffected by leukemia.

Answer to Question 2

ANS: A
Aplastic anemia refers to a bone marrowfailure condition in which the formed elements of the blood are simultaneously depressed. Sickle cell anemia is a hemoglobinopathy in which normal adult hemoglobin is partly or completely replaced by abnormal sickle hemoglobin. Thalassemia major is a group of blood disorders characterized by deficiency in the production rate of specific hemoglobin globin chains. Iron deficiency anemia results in a decreased amount of circulating red cells.