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More than 2,500 barbiturates have been synthesized. At the height of their popularity, about 50 were marketed for human use.
Nearly all drugs pass into human breast milk. How often a drug is taken influences the amount of drug that will pass into the milk. Medications taken 30 to 60 minutes before breastfeeding are likely to be at peak blood levels when the baby is nursing.
There are approximately 3 million unintended pregnancies in the United States each year.
More than 150,000 Americans killed by cardiovascular disease are younger than the age of 65 years.
Disorders that may affect pharmacodynamics include genetic mutations, malnutrition, thyrotoxicosis, myasthenia gravis, Parkinson's disease, and certain forms of insulin-resistant diabetes mellitus.