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Cocaine was isolated in 1860 and first used as a local anesthetic in 1884. Its first clinical use was by Sigmund Freud to wean a patient from morphine addiction. The fictional character Sherlock Holmes was supposed to be addicted to cocaine by injection.
Urine turns bright yellow if larger than normal amounts of certain substances are consumed; one of these substances is asparagus.
In women, pharmacodynamic differences include increased sensitivity to (and increased effectiveness of) beta-blockers, opioids, selective serotonin reuptake inhibitors, and typical antipsychotics.
There are over 65,000 known species of protozoa. About 10,000 species are parasitic.
According to the FDA, adverse drug events harmed or killed approximately 1,200,000 people in the United States in the year 2015.