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In women, pharmacodynamic differences include increased sensitivity to (and increased effectiveness of) beta-blockers, opioids, selective serotonin reuptake inhibitors, and typical antipsychotics.
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Aspirin is the most widely used drug in the world. It has even been recognized as such by the Guinness Book of World Records.
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Drug-induced pharmacodynamic effects manifested in older adults include drug-induced renal toxicity, which can be a major factor when these adults are experiencing other kidney problems.
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After 5 years of being diagnosed with rheumatoid arthritis, one every three patients will no longer be able to work.
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In 1864, the first barbiturate (barbituric acid) was synthesized.