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The first oral chemotherapy drug for colon cancer was approved by FDA in 2001.
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Cocaine was isolated in 1860 and first used as a local anesthetic in 1884. Its first clinical use was by Sigmund Freud to wean a patient from morphine addiction. The fictional character Sherlock Holmes was supposed to be addicted to cocaine by injection.
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In 1864, the first barbiturate (barbituric acid) was synthesized.
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The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.
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Computer programs are available that crosscheck a new drug's possible trade name with all other trade names currently available. These programs detect dangerous similarities between names and alert the manufacturer of the drug.