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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
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Asthma occurs in one in 11 children and in one in 12 adults. African Americans and Latinos have a higher risk for developing asthma than other groups.
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There are approximately 3 million unintended pregnancies in the United States each year.
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In 1864, the first barbiturate (barbituric acid) was synthesized.
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Asthma cases in Americans are about 75% higher today than they were in 1980.