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There are major differences in the metabolism of morphine and the illegal drug heroin. Morphine mostly produces its CNS effects through m-receptors, and at k- and d-receptors. Heroin has a slight affinity for opiate receptors. Most of its actions are due to metabolism to active metabolites (6-acetylmorphine, morphine, and morphine-6-glucuronide).
Human stomach acid is strong enough to dissolve small pieces of metal such as razor blades or staples.
Urine turns bright yellow if larger than normal amounts of certain substances are consumed; one of these substances is asparagus.
In most cases, kidneys can recover from almost complete loss of function, such as in acute kidney (renal) failure.
In 1885, the Lloyd Manufacturing Company of Albany, New York, promoted and sold "Cocaine Toothache Drops" at 15 cents per bottle! In 1914, the Harrison Narcotic Act brought the sale and distribution of this drug under federal control.