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In women, pharmacodynamic differences include increased sensitivity to (and increased effectiveness of) beta-blockers, opioids, selective serotonin reuptake inhibitors, and typical antipsychotics.
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There are more sensory neurons in the tongue than in any other part of the body.
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There are more nerve cells in one human brain than there are stars in the Milky Way.
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If all the neurons in the human body were lined up, they would stretch more than 600 miles.
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Cocaine was isolated in 1860 and first used as a local anesthetic in 1884. Its first clinical use was by Sigmund Freud to wean a patient from morphine addiction. The fictional character Sherlock Holmes was supposed to be addicted to cocaine by injection.