|
|
Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
Disorders that may affect pharmacodynamics include genetic mutations, malnutrition, thyrotoxicosis, myasthenia gravis, Parkinson's disease, and certain forms of insulin-resistant diabetes mellitus.
Eat fiber! A diet high in fiber can help lower cholesterol levels by as much as 10%.
More than 2,500 barbiturates have been synthesized. At the height of their popularity, about 50 were marketed for human use.
Human stomach acid is strong enough to dissolve small pieces of metal such as razor blades or staples.