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Most childhood vaccines are 90–99% effective in preventing disease. Side effects are rarely serious.
Ether was used widely for surgeries but became less popular because of its flammability and its tendency to cause vomiting. In England, it was quickly replaced by chloroform, but this agent caused many deaths and lost popularity.
Pope Sylvester II tried to introduce Arabic numbers into Europe between the years 999 and 1003, but their use did not catch on for a few more centuries, and Roman numerals continued to be the primary number system.
Bacteria have been found alive in a lake buried one half mile under ice in Antarctica.
More than 2,500 barbiturates have been synthesized. At the height of their popularity, about 50 were marketed for human use.