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The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.
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The people with the highest levels of LDL are Mexican American males and non-Hispanic black females.
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In Eastern Europe and Russia, interferon is administered intranasally in varied doses for the common cold and influenza. It is claimed that this treatment can lower the risk of infection by as much as 60–70%.
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The FDA recognizes 118 routes of administration.
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Disorders that may affect pharmacodynamics include genetic mutations, malnutrition, thyrotoxicosis, myasthenia gravis, Parkinson's disease, and certain forms of insulin-resistant diabetes mellitus.