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Cocaine was isolated in 1860 and first used as a local anesthetic in 1884. Its first clinical use was by Sigmund Freud to wean a patient from morphine addiction. The fictional character Sherlock Holmes was supposed to be addicted to cocaine by injection.
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According to the FDA, adverse drug events harmed or killed approximately 1,200,000 people in the United States in the year 2015.
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Today, nearly 8 out of 10 pregnant women living with HIV (about 1.1 million), receive antiretrovirals.
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Drug-induced pharmacodynamic effects manifested in older adults include drug-induced renal toxicity, which can be a major factor when these adults are experiencing other kidney problems.
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Asthma cases in Americans are about 75% higher today than they were in 1980.