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Disorders that may affect pharmacodynamics include genetic mutations, malnutrition, thyrotoxicosis, myasthenia gravis, Parkinson's disease, and certain forms of insulin-resistant diabetes mellitus.
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Warfarin was developed as a consequence of the study of a strange bleeding disorder that suddenly occurred in cattle on the northern prairies of the United States in the early 1900s.
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This year, an estimated 1.4 million Americans will have a new or recurrent heart attack.
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Medication errors are more common among seriously ill patients than with those with minor conditions.
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The most destructive flu epidemic of all times in recorded history occurred in 1918, with approximately 20 million deaths worldwide.