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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
Pope Sylvester II tried to introduce Arabic numbers into Europe between the years 999 and 1003, but their use did not catch on for a few more centuries, and Roman numerals continued to be the primary number system.
In 1835 it was discovered that a disease of silkworms known as muscardine could be transferred from one silkworm to another, and was caused by a fungus.
Despite claims by manufacturers, the supplement known as Ginkgo biloba was shown in a study of more than 3,000 participants to be ineffective in reducing development of dementia and Alzheimer’s disease in older people.
HIV testing reach is still limited. An estimated 40% of people with HIV (more than 14 million) remain undiagnosed and do not know their infection status.
![Cast of Isotelus rex, the largest known trilobite from the middle to upper Ordovician of North Ameri](https://biology-forums.com/gallery/47/medium_12359_29_04_12_6_05_29.jpeg)
![The Hepatic Portal Blood Supply The liver receives water, minerals, and nutrients from the digestive](https://biology-forums.com/gallery/47/medium_32338_23_05_15_9_46_26_21855858.jpeg)