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In 1864, the first barbiturate (barbituric acid) was synthesized.
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Lower drug doses for elderly patients should be used first, with titrations of the dose as tolerated to prevent unwanted drug-related pharmacodynamic effects.
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Cancer has been around as long as humankind, but only in the second half of the twentieth century did the number of cancer cases explode.
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Studies show that systolic blood pressure can be significantly lowered by taking statins. In fact, the higher the patient's baseline blood pressure, the greater the effect of statins on his or her blood pressure.
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In 1844, Charles Goodyear obtained the first patent for a rubber condom.