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In 1844, Charles Goodyear obtained the first patent for a rubber condom.
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In most cases, kidneys can recover from almost complete loss of function, such as in acute kidney (renal) failure.
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Disorders that may affect pharmacodynamics include genetic mutations, malnutrition, thyrotoxicosis, myasthenia gravis, Parkinson's disease, and certain forms of insulin-resistant diabetes mellitus.
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Of the estimated 2 million heroin users in the United States, 600,000–800,000 are considered hardcore addicts. Heroin addiction is considered to be one of the hardest addictions to recover from.
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The ratio of hydrogen atoms to oxygen in water (H2O) is 2:1.