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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
Once thought to have neurofibromatosis, Joseph Merrick (also known as "the elephant man") is now, in retrospect, thought by clinical experts to have had Proteus syndrome. This endocrine disease causes continued and abnormal growth of the bones, muscles, skin, and so on and can become completely debilitating with severe deformities occurring anywhere on the body.
More than 150,000 Americans killed by cardiovascular disease are younger than the age of 65 years.
Drying your hands with a paper towel will reduce the bacterial count on your hands by 45–60%.
Earwax has antimicrobial properties that reduce the viability of bacteria and fungus in the human ear.
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