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In 1844, Charles Goodyear obtained the first patent for a rubber condom.
Earwax has antimicrobial properties that reduce the viability of bacteria and fungus in the human ear.
More than 2,500 barbiturates have been synthesized. At the height of their popularity, about 50 were marketed for human use.
In Eastern Europe and Russia, interferon is administered intranasally in varied doses for the common cold and influenza. It is claimed that this treatment can lower the risk of infection by as much as 60–70%.
Signs of depression include feeling sad most of the time for 2 weeks or longer; loss of interest in things normally enjoyed; lack of energy; sleep and appetite disturbances; weight changes; feelings of hopelessness, helplessness, or worthlessness; an inability to make decisions; and thoughts of death and suicide.