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Throughout history, plants containing cardiac steroids have been used as heart drugs and as poisons (e.g., in arrows used in combat), emetics, and diuretics.
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The first oral chemotherapy drug for colon cancer was approved by FDA in 2001.
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In the United States, an estimated 50 million unnecessary antibiotics are prescribed for viral respiratory infections.
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Disorders that may affect pharmacodynamics include genetic mutations, malnutrition, thyrotoxicosis, myasthenia gravis, Parkinson's disease, and certain forms of insulin-resistant diabetes mellitus.
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More than nineteen million Americans carry the factor V gene that causes blood clots, pulmonary embolism, and heart disease.