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The FDA recognizes 118 routes of administration.
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Patients who cannot swallow may receive nutrition via a parenteral route—usually, a catheter is inserted through the chest into a large vein going into the heart.
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In 1844, Charles Goodyear obtained the first patent for a rubber condom.
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Intradermal injections are somewhat difficult to correctly administer because the skin layers are so thin that it is easy to accidentally punch through to the deeper subcutaneous layer.
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In 1864, the first barbiturate (barbituric acid) was synthesized.