What is the critical alpha1-antitrypsin level below which lung ...

[chads108]

What is the critical alpha1-antitrypsin level below which lung elastin is attacked and broken down?
 
  a. 57 mg/dl
  b. 84 mg/dl
  c. 100 mg/dl
  d. 150 mg/dl

Question 2

The mechanisms of airway obstruction in COPD include which of the following? 1. Airway remodeling 2. Inflammation and obstruction of small airway 3. Loss of elasticity 4. Active bronchospasm
 
  a. 1 and 2 only
  b. 1 and 4 only
  c. 2, 3, and 4 only
  d. 3 and 4 only

[bulacsom]

Answer to Question 1

ANS: A
In the face of a severe deficiency of alpha1-antitrypsin (i.e., when serum levels fall below a pro-tective threshold value of 11 mol/L, or 57 mg/dl), neutrophil elastase may go unchecked, caus-ing breakdown of elastin and resulting dissolution of alveolar walls.

Answer to Question 2

ANS: C
The mechanisms of airflow obstruction in COPD include inflammation and obstruction of small airways (<2 bronchospasm.

[chads108]

Correct answers!

[bulacsom]

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