Why is lipid diffusion an important mechanism for drug absorption?
a. Many epithelial membranes must be crossed if a drug is to distribute in the body and reach its target organ.
b. Epithelial cells do not have lipid membranes, so a drug must be water-soluble to diffuse across such a membrane.
c. It is directly related to the proportion of a drug that reaches the systemic circulation.
d. Lipid diffusion has no importance in drug absorption because the body has very few epithelial membranes drugs must cross.
Question 2
A special case of synergism in which one drug has no effect but can increase the activity of another drug is known as
a. potency.
b. hypersensitivity.
c. potentiation.
d. additivity.
Subcutaneous drug administration: (a) cross section of skin showing depth of needle insertion;
First-pass effect: (a) drugs are absorbed; (b) drugs enter hepatic portal circulation and go directl
Diffusion
The four processes of pharmacokinetics: absorption, distribution, metabolism, and excretion.
Proposed mechanism of glutamine-dependent amidotransferases