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In women, pharmacodynamic differences include increased sensitivity to (and increased effectiveness of) beta-blockers, opioids, selective serotonin reuptake inhibitors, and typical antipsychotics.
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There are 20 feet of blood vessels in each square inch of human skin.
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The tallest man ever known was Robert Wadlow, an American, who reached the height of 8 feet 11 inches. He died at age 26 years from an infection caused by the immense weight of his body (491 pounds) and the stress on his leg bones and muscles.
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The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.
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In 1844, Charles Goodyear obtained the first patent for a rubber condom.