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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
In the United States, congenital cytomegalovirus causes one child to become disabled almost every hour. CMV is the leading preventable viral cause of development disability in newborns. These disabilities include hearing or vision loss, and cerebral palsy.
Asthma cases in Americans are about 75% higher today than they were in 1980.
More than nineteen million Americans carry the factor V gene that causes blood clots, pulmonary embolism, and heart disease.
Thyroid conditions cause a higher risk of fibromyalgia and chronic fatigue syndrome.