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Pope Sylvester II tried to introduce Arabic numbers into Europe between the years 999 and 1003, but their use did not catch on for a few more centuries, and Roman numerals continued to be the primary number system.
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When intravenous medications are involved in adverse drug events, their harmful effects may occur more rapidly, and be more severe than errors with oral medications. This is due to the direct administration into the bloodstream.
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In 1844, Charles Goodyear obtained the first patent for a rubber condom.
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The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.
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When blood is exposed to air, it clots. Heparin allows the blood to come in direct contact with air without clotting.