A female patient taking phenytoin (Dilantin) is considering ...

[magmichele12]

A female patient taking phenytoin (Dilantin) is considering becoming pregnant. Which of the following statements correctly describes distribution of the drug to the fetus?
 
  a. It crosses the placenta and enters breast milk.
  b. It crosses the placenta but does not enter breast milk.
  c. It does not cross the placenta but enters breast milk.
  d. It does not cross the placenta or enter breast milk.

Question 2

The patient has been placed on zolmitriptan (Zomig). Which of the following drugs should the patient avoid receiving concurrently?
 
  a. Macrolide antibiotics
  b. Beta blockers
  c. Calcium channel blockers
  d. Antihypertensives

[ndhahbi]

Answer to Question 1

ANS: A
The hydantoins cross the placenta and enter breast milk. Fetal hydantoin syndrome is possible with phenytoin, producing craniofacial abnormalities, congenital heart defects, and microcephaly, among other birth defects.

Answer to Question 2

ANS: A
Many drugs interact with triptans; the primary concern is sustained vasoconstriction and vaso-spasm leading to ischemia. These drugs include macrolide antibiotics, azole antifungal drugs, and ergotamine, caffeine, nefazodone, nelfinavir, ritonavir, and CYP 3A4 inhibitors.

[magmichele12]

Thanks for the timely response, appreciate it

[ricroger]

TYSM