Author Question: A client with very high serum triglyceride levels is prescribed the fibric acid derivative ... (Read 125 times)

joblessjake · **on:** Jul 23, 2018

A client with very high serum triglyceride levels is prescribed the fibric acid derivative clofibrate. The nurse understands that this drug would be contraindicated if the client has which condition?

A) Endocrine disorder
B) Primary biliary cirrhosis
C) Arterial bleeding
D) Respiratory depression

Question 2

A client is receiving pravastatin to reduce the risk of coronary heart disease due to hyperlipidemia. The client is also receiving amiodarone for an arrhythmia.

The nurse understands that the client is at risk for which of the following based on these two drugs?

A) Increased anticoagulant effect
B) Increased hypoglycemic effect
C) Increased risk of myopathy
D) Decreased effects of pravastatin

missalyssa26 · **Reply #1 on:** Jul 23, 2018

Answer to Question 1

Ans: B
Feedback:
The fibric acid derivative clofibrate is contraindicated in clients with primary biliary cirrhosis. The use of clofibrate is not contraindicated in clients with an endocrine disorder. The HMG-CoA reductase inhibitors are used with caution in clients with a history of endocrine disorders. Niacin is contraindicated in clients with arterial bleeding. The fibric acid derivative clofibrate is not contraindicated in clients with respiratory depression.

Answer to Question 2

Ans: C
Feedback:
When the HMG-CoA reductase inhibitor pravastatin is administered with amiodarone, the nurse should monitor the client for increased risk of myopathy as an effect of the interaction between the two drugs. Increased anticoagulant effect is observed in clients receiving warfarin along with pravastatin. Increased hypoglycemic effects are observed in clients receiving sulfonylureas with fibric acid derivatives. The interaction of pravastatin with amiodarone does not decrease the effect of pravastatin.