Author Question: Which drugs are often combined with statins for an enhanced lipid-lowering effect to lower ... (Read 92 times)

penza · **on:** Jul 23, 2018

Which drugs are often combined with statins for an enhanced lipid-lowering effect to lower triglycerides?

1. Bile acid binding drugs
2. Niacin
3. Fibric acid
4. HMG-CoA

Question 2

The client has been taking niacin. Which statement by the client describes how this medication works?

1.It decreases VLDL levels and increases HDL levels.
2. The medication works immediately.
3. It works by binding bile acid in the intestines.
4. It is a vitamin C replacement.

cloudre37 · **Reply #1 on:** Jul 23, 2018

Answer to Question 1

3

Rationale 1:Bile acid binding drugs use the intestinal tract to remove cholesterol. They are not combined with statins.
Rationale 2:Niacin is a water-soluble B-complex vitamin which decreases VLDL levels. This medication can be used with other drug classes to lower lipid levels.
Rationale 3:Fibrins and statins are used for patients with excessive triglyceride and VLDL levels.
Rationale 4:HMG-CoA reductase inhibitors are also referred to as statins.

Global Rationale: The fibric acid drugs or fibrates are older medications that have been replaced by statins. They are used in combination with the statins to produce and enhance lipid-lowering effect for patients with excessive triglyceride and VLDL levels.

Answer to Question 2

1

Rationale 1:It decreases VLDL levels and increases HDL levels.
Rationale 2:Niacin may take a month or longer to achieve.
Rationale 3:Bile acid binding drugs can reduce LDL levels by increasing cholesterol excretion in the intestine.
Rationale 4:Niacin is a water-soluble B-complex vitamin.

Global Rationale: Niacin, also called nicotinic acid, is a water-soluble B-complex vitamin whose primary pharmacologic action is to decrease VLDL levels. When VLDL is diminished, the patient also experiences a reduction in LDL-cholesterol and triglyceride levels. Niacin also increases HDL levels.