A patient's genetic testing reveals a change in CYP2A6. The nurse ...

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A patient's genetic testing reveals a change in CYP2A6. The nurse would plan which interventions based on this discovery? Note: Credit will be given only if all correct choices and no incorrect choices are selected. Standard Text: Select all that apply.
 
  1. Teaching the patient to avoid caffeine-containing drugs.
  2. Planning additional time and interventions to help the patient stop smoking.
  3. Use of an alternative to the drug warfarin.
  4. Increased surveillance for the development of lung cancer.
  5. Frequent monitoring of blood pressure.

Question 2

A hospice patient has been receiving oral pain medication for several weeks. The patient started with 4 mg of the drug, and each week has had to increase the amount by 23 mg to obtain adequate pain relief. The nurse recognizes that the patient
 
  1. has developed immunity to the drug.
  2. has developed a tolerance to the drug.
  3. has developed a physiologic addiction to the drug.
  4. has developed a psychological addiction to the drug.

[dmurph1496]

Answer to Question 1

2,4
Rationale 1: CYP2A6 is not associated with caffeine.
Rationale 2: CYP2A6 reduction may make smoking cessation more difficult.
Rationale 3:.CYP2C9 is associated with reduced metabolism of warfarin.
Rationale 4: CYP2A6 reduction may increase risk of lung cancer.
Rationale 5: CYP2A6 is not associated with blood pressure level.
Global Rationale: CYP2A6 reduction may make smoking cessation more difficult and increases risk of lung cancer. It is not associated with caffeine or blood pressure level. CYP2C9 is associated with reduced metabolism of warfarin.

Answer to Question 2

2
Rationale 1: Drug immunity is more appropriately used when discussing the immune system.
Rationale 2: Drug tolerance occurs when the body adapts to a substance after repeated administration.
Rationale 3: Although addictions are possible, the situation presented best describes drug tolerance, not addiction.
Rationale 4: Although addictions are possible, the situation presented best describes drug tolerance, not addiction.
Global Rationale: Drug tolerance occurs when the body adapts to a substance after repeated administration. Although addictions are possible, the situation presented best describes drug tolerance, not addiction. Drug immunity is a term that is often confused with drug tolerance. Drug immunity is more appropriately used when discussing the immune system.

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Gracias!

[Chelseyj.hasty]

Thanks for the timely response, appreciate it