Answer to Question 1
Correct Answer: 2
Rationale 1: Niacin does not prevent peripheral neuropathy.
Rationale 2: Pyridoxine prevents peripheral neuropathy.
Rationale 3: Cyanocobalamin does not prevent peripheral neuropathy.
Rationale 4: Neurontin does not prevent neuropathy.
Global Rationale: Pregnant patients should receive isoniazid therapy supplemented with pyridoxine (vitamin B6), which has been shown to prevent peripheral neuropathy. The other drugs do not have this action.
Answer to Question 2
Correct Answer: 1,4
Rationale 1: The initial phase of therapy includes 2 months of daily therapy with isoniazid.
Rationale 2: The initial phase of therapy does not include 9 months of ethambutol therapy.
Rationale 3: The initial phase of therapy does not include 4 months of daily ethamubutol therapy.
Rationale 4: The initial phase of therapy includes 2 months of daily therapy with rifampin.
Rationale 5: The initial phase of therapy does not include pyrazinamide two to three times a week for 4 months.
Global Rationale: Initial treatment includes two months of daily therapy with isoniazid, rifampin (Rifadin, Rimactane), pyrazinamide (PZA), and ethambutol (Myambutol). If C&S results show that the strain is sensitive to the first three drugs, ethambutol is dropped from the regimen
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