A client who takes avorstatin (Lipitor) daily has been prescribed ...

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A client who takes avorstatin (Lipitor) daily has been prescribed erythromycin for sinusitis.
 
  To prevent consequences of an adverse effect of this combination of drugs, it is most important for the nurse to monitor this client for which clinical manifestation?
  1. Lack of expected response to erythromycin.
  2. New onset of muscle pain.
  3. Abdominal pain and cramping.
  4. Bleeding from the oral cavity and bruising.

Question 2

The nurse is reviewing the adverse effects associated with statins with a client who is prescribed this classification of medication to reduce blood cholesterol levels.
 
  The nurse knows the client has understood the teaching when the client states which serious adverse effects associated with statins?
  Standard Text: Select all that apply.
  1. Headache
  2. Abdominal pain
  3. Myopathy
  4. Muscle or joint pain
  5. Rhabdomyolysis

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Answer to Question 1

Correct Answer: 2
Rationale 1: Avorstatin (Lipitor) does not decrease the therapeutic effect of erythromycin.
Rationale 2: Muscle pain may be a sign of rhabdomyolysis, which is a life-threatening condition. The risk of rhabdomyolysis is increased for clients taking a macrolide drug such as erythromycin, because macrolides significantly increase blood levels of avorstatin.
Rationale 3: Abdominal pain and cramping are experienced by some clients as a side effect of erythromycin, but this effect is not enhanced by the interaction with avorstatin (Lipitor).
Rationale 4: Coagulation is not altered as a consequence of the interaction of these two drugs.
Global Rationale: Muscle pain may be a sign of rhabdomyolysis, which is a life-threatening condition. The risk of rhabdomyolysis is increased for clients taking a macrolide drug such as erythromycin, because macrolides significantly increase blood levels of avorstatin. Avorstatin (Lipitor) does not decrease the therapeutic effect of erythromycin. Abdominal pain and cramping are experienced by some clients as a side effect of erythromycin, but this effect is not enhanced by the interaction with avorstatin (Lipitor). Coagulation is not altered as a consequence of the interaction of these two drugs.

Answer to Question 2

Correct Answer: 3,5
Rationale 1: A headache is an example of a minor adverse effect associated with statins.
Rationale 2: Abdominal pain is an example of a minor adverse effect associated with statins.
Rationale 3: Severe myopathy is a rare but serious adverse effect associated with statins.
Rationale 4: Muscle or joint pain is an example of a minor adverse effect associated with statins.
Rationale 5: Rhabdomyolysis is an example of a rare but serious adverse effect associated with statins.
Global Rationale: Severe myopathy is a rare but serious adverse effect associated with statins. Rhabdomyolysis is an example of a rare but serious adverse effect associated with statins. Headache, abdominal pain, and muscle or joint pain are examples of a minor adverse effects associated with statins.