A client is receiving an antibiotic with the potential for ...

[vicky]

A client is receiving an antibiotic with the potential for nephrotoxicity. Which item should the nurse should plan to monitor?
 
  1. Urinary concentration of the drug
  2. Route of drug administration
  3. Plasma levels of the drug
  4. Rate of intravenous administration

Question 2

The nurse is preparing to medicate a client for a migraine headache. The nurse should choose the drug with which half-life?
 
  1. 10 to 20 hours
  2. 5 to 10 days
  3. 2 to 3 hours
  4. 1 to 3 minutes

[Eunice618]

Answer to Question 1

Correct Answer: 3
Rationale 1: The urinary concentration of a drug will not provide an accurate measurement of nephrotoxicity.
Rationale 2: The route of administration will not determine nephrotoxicity.
Rationale 3: Plasma levels of a drug are an indicator of whether a drug is at a therapeutic or toxic level, and provide information as to whether a drug dosage needs adjustment.
Rationale 4: Although the rate at which a drug is administered intravenously can affect plasma levels and irritation to the vein, it would not provide the best measure of nephrotoxicity.
Global Rationale: Plasma levels of a drug are an indicator of whether a drug is at a therapeutic or toxic level, and provide information as to whether a drug dosage needs adjustment. The urinary concentration of a drug will not provide an accurate measurement of nephrotoxicity. The route of administration will not determine nephrotoxicity. Although the rate at which a drug is administered intravenously can affect plasma levels and irritation to the vein, it would not provide the best measure of nephrotoxicity.

Answer to Question 2

Correct Answer: 3
Rationale 1: A half-life of 10 to 20 hours is longer than would be needed to provide migraine pain relief.
Rationale 2: A half-life of 5 to 10 days is longer than would be needed to provide migraine pain relief.
Rationale 3: A drug with a half-life of 2 to 3 hours will be reduced by 50 in 2 to 3 hours, providing adequate time for the client to obtain pain relief.
Rationale 4: A drug with a half-life of 1 to 3 minutes would be eliminated in a very short time period and would not provide adequate pain relief.
Global Rationale: A drug with a half-life of 2 to 3 hours will be reduced by 50 in 2 to 3 hours, providing adequate time for the client to obtain pain relief. A half-life of 10 to 20 hours is longer than would be needed to provide migraine pain relief. A half-life of 5 to 10 days is longer than would be needed to provide migraine pain relief. A drug with a half-life of 1 to 3 minutes would be eliminated in a very short time period and would not provide adequate pain relief.

[vicky]

Thanks for the timely response, appreciate it

[mohan]

Excellent