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Author Question: If a drug has a half-life of 12 hours and is given twice daily starting at 0800 on a Monday, when ... (Read 83 times)

ereecah

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on: Jul 23, 2018
If a drug has a half-life of 12 hours and is given twice daily starting at 0800 on a Monday, when will a steady state be achieved?
 
  a. 0800 on Tuesday
  b. 0800 on Wednesday
  c. 0800 on Thursday
  d. 0800 on Friday

Question 2

The nurse gives a medication to a patient with a history of liver disease. The nurse will monitor this patient for
 
  a. decreased drug effects.
  b. increased drug effects.
  c. decreased therapeutic range.
  d. increased therapeutic range.


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Brummell1998

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Reply #1 on: Jul 23, 2018
Answer to Question 1

ANS: B
Steady-state levels occur at 3 to 5 half-lives. Wednesday at 0800 is 4 half-lives from the original dose.

Answer to Question 2

ANS: B
Liver diseases such as cirrhosis and hepatitis alter drug metabolism by inhibiting the drug-metabolizing enzymes in the liver. When the drug metabolism rate is decreased, excess drug accumulation can occur and lead to toxicity.


ereecah

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Reply 2 on: Jul 23, 2018
Thanks for the timely response, appreciate it

atrochim

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Reply 3 on: Yesterday
Gracias!

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