Author Question: If a drug has a half-life of 12 hours and is given twice daily starting at 0800 on a Monday, when ... (Read 49 times)

ereecah · **on:** Jul 23, 2018

If a drug has a half-life of 12 hours and is given twice daily starting at 0800 on a Monday, when will a steady state be achieved?

a. 0800 on Tuesday
b. 0800 on Wednesday
c. 0800 on Thursday
d. 0800 on Friday

Question 2

The nurse gives a medication to a patient with a history of liver disease. The nurse will monitor this patient for

a. decreased drug effects.
b. increased drug effects.
c. decreased therapeutic range.
d. increased therapeutic range.

Brummell1998 · **Reply #1 on:** Jul 23, 2018

Answer to Question 1

ANS: B
Steady-state levels occur at 3 to 5 half-lives. Wednesday at 0800 is 4 half-lives from the original dose.

Answer to Question 2

ANS: B
Liver diseases such as cirrhosis and hepatitis alter drug metabolism by inhibiting the drug-metabolizing enzymes in the liver. When the drug metabolism rate is decreased, excess drug accumulation can occur and lead to toxicity.