The nurse prepares to change a patient's medication from an ...

[awywial]

The nurse prepares to change a patient's medication from an intravenous to an oral form and notes that the oral form is ordered in a higher dose. The nurse understands that this is due to differences in
 
  a. bioavailability.
  b. pinocytosis.
  c. protein binding.
  d. tachyphylaxis.

Question 2

The nurse is preparing to administer a drug and learns that it binds to protein at a rate of 90. The patient's serum albumin level is low. The nurse will observe the patient for
 
  a. decreased drug absorption.
  b. decreased drug interactions.
  c. decreased drug toxicity.
  d. increased drug effects.

[allisonblackmore]

Answer to Question 1

ANS: A
Oral drugs may have less bioavailability because a lower percentage of the drug reaches the systemic circulation. Pinocytosis refers to the process by which cells carry a solute across a membrane. Protein binding can occur with both routes. Tachyphylaxis describes a rapid decrease in response to drugs that occurs when tolerance develops quickly.

Answer to Question 2

ANS: D
Drugs that are highly protein-bound bind with albumin and other proteins, leaving less free drug in circulation. If a patient has a low albumin, the drug is not bound, and there is more free drug to cause drug effects. There would be increased absorption, increased interactions with other drugs, and increased toxicity.

[awywial]

TY

[allisonblackmore]

You're welcome