Author Question: According to studies of estrogen/progestin therapy (EPT), what are its known benefits? (Select all ... (Read 53 times)

NguyenJ · **on:** Jul 23, 2018

According to studies of estrogen/progestin therapy (EPT), what are its known benefits? (Select all that apply.)

a. Cardiovascular protection in older patients
b. Decreased osteoporosis risk
c. Glycemic control
d. Improved wound healing
e. Prevention of colorectal cancer

Question 2

A patient with Parkinson's disease is taking levodopa/carbidopa Sinemet and reports occasional periods of loss of drug effect lasting from minutes to several hours.

The nurse questions the patient further and discovers that these episodes occur at different times related to the medication administration. The nurse will contact the provider to discuss: a. administering a cate-chol-O-methyltransferase (COMT) inhi-bitor, such as entacapone.
b. adding the DA-releasing agent amanta-dine to the regimen.
c. giving a direct-acting dopamine agonist.
d. shortening the dosing interval of levodo-pa/carbidopa.

marict · **Reply #1 on:** Jul 23, 2018

Answer to Question 1

B, C, D
EPT can lower osteoporosis risk, improve glycemic control, and aid in wound healing. Prepara-tions with estrogen alone can provide cardiovascular protection or help prevent colorectal cancer, but not preparations containing progestin.

Answer to Question 2

A
This patient is describing abrupt loss of effect, or the off phenomenon, which is treated with entacapone or another COMT inhibitor. Amantadine is used to treat dyskinesias. A direct-acting dopamine agonist is useful for gradual loss of effect, which occurs at the end of the dosing inter-val as the dose is wearing off. Shortening the dosing interval does not help with abrupt loss of effect.