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Author Question: Someone asks a nurse about a new drug that is in preclinical testing and wants to know why it cannot ... (Read 29 times)

maychende

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on: Jul 23, 2018
Someone asks a nurse about a new drug that is in preclinical testing and wants to know why it cannot be used to treat a friend's illness. Which statement by the nurse is correct?
 
  a. A drug at this stage of development can be used only in patients with serious dis-ease.
  b. At this stage of drug development, the safety and usefulness of the medication is unknown.
  c. Clinical trials must be completed to make sure the drug is safe to use in humans.
  d. Until postmarketing surveillance data are available, the drug cannot be used.

Question 2

A child will begin taking methylphenidate Ritalin for attention-deficit/hyperactivity disorder. Important baseline information about this patient will include:
 
  a. results of an electrocardiogram (ECG).
  b. family history of psychosis.
  c. height and weight.
  d. renal function.


potomatos

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Reply #1 on: Jul 23, 2018
Answer to Question 1

B
Preclinical testing must be completed before drugs can be tested in humans. In this stage, drugs are evaluated for toxicities, pharmacokinetic properties, and potentially useful effects. Some drugs can be used in patients before completion of Phase III studies, but this is after preclinical testing is complete. Clinical trials proceed in stages, and each stage has guidelines defining how a new drug may be used and which patients may receive it. Postmarketing surveillance takes place after a drug is in general use.

Answer to Question 2

C
Side effects of methylphenidate include a reduced appetite, and children taking these drugs should be monitored for growth suppression. Baseline height and weight measurements help with this ongoing assessment. The value of an ECG for children has not been proven, except when known heart disease is a factor. Excessive use of stimulants can produce a state of psychosis but is not related to the family history. Renal function tests are not indicated.


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maychende

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Reply #2 on: Jul 23, 2018
Both answers were spot on, thank you once again


potomatos

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Reply #3 on: Jul 23, 2018
Great! Please up vote :D


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