The nurse is caring for a patient scheduled for surgery who is to ...

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The nurse is caring for a patient scheduled for surgery who is to receive a barbiturate as part of the planned balanced anesthesia.
 
  What drugs, if taken by the patient, could result in a clinically important drugdrug interaction with the barbiturate? (Select all that apply.) A) Thyroid hormone
  B) Ibuprofen
  C) Oral contraceptive
  D) Theophylline
  E) Anticoagulant

Question 2

What H2 antagonist would the nurse consider the drug of choice for a patient with advanced liver failure?
 
  A) Cimetidine
  B) Nizatidine
  C) Ranitidine
  D) Famotidine

[Toya9913]

Answer to Question 1

C, D, E
Feedback:
Caution must be used when these drugs are used with any other central nervous system suppressants. Barbiturates can cause decreased effectiveness of theophylline, oral anticoagulants, beta-blockers, corticosteroids, hormonal contraceptives, phenylbutazones, metronidazole, quinidine, and carbamazepine. Combinations of barbiturate anesthetics and narcotics may produce apnea more commonly than occurs with other analgesics. Thyroid hormone and ibuprofen have no known drug interactions with barbiturates.

Answer to Question 2

B
Feedback:
Nizatidine differs from the other three drugs in that it is eliminated by the kidneys, with no first-pass metabolism in the liver. It is the drug of choice for patients with liver disease or dysfunction.

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TYSM

[JaynaD87]

Thanks for the timely response, appreciate it