Drugs are metabolized mainly by the liver via phase I or phase II ...

[JMatthes]

Drugs are metabolized mainly by the liver via phase I or phase II reactions. The purpose of both of these types of reactions is to:
 
  1. Inactivate prodrugs before they can be activated by target tissues
  2. Change the drugs so they can cross plasma membranes
  3. Change drug molecules to a form that an excretory organ can excrete
  4. Make these drugs more ionized and polar to facilitate excretion

Question 2

Drugs administered via IV:
 
  1. Need to be lipid soluble in order to be easily absorbed
  2. Begin distribution into the body immediately
  3. Are easily absorbed if they are nonionized
  4. May use pinocytosis to be absorbed

[reversalruiz]

Answer to Question 1

3

Answer to Question 2

2

[JMatthes]

Thanks for the timely response, appreciate it

[lindahyatt42]

Excellent