Some persons metabolize isoniazid (INH) more rapidly than others. ...

[leilurhhh]

Some persons metabolize isoniazid (INH) more rapidly than others. It is important for the nurse to remember that:
 
  a. nearly all Caucasians and African Americans are rapid acetylators.
  b. nearly all Asians are slow acetylators.
  c. slow acetylators are more likely to experience drug toxicity.
  d. rapid acetylators have increased isoniazid effectiveness

Question 2

Two days later, the client calls the nurse to report a sore throat, fever, and jaundice. The nurse should advise the client to:
 
  a. decrease the dose of the sulfonamide.
  b. go to bed and rest.
  c. call the health care provider tomorrow, if he feels worse.
  d. stop the sulfonamide and see the health care provider as soon as possible.

[nanny]

Answer to Question 1

ANS: C

Feedback
A Incorrect: Fifty percent of Caucasians and African Americans are slow acetylators.
B Incorrect: The majority of Asians and Eskimos are rapid acetylators.
C Correct: Slow acetylators are more likely to have the drug accumulate in their bodies to toxic levels.
D Incorrect: Regardless of how rapid or slowly INH is metabolized, it does not affects its effectiveness.

Answer to Question 2

ANS: D

Feedback
A Incorrect: The drug must be stopped, and the client should see his prescriber as soon as possible, as these may be manifestations of a blood dyscrasia.
B Incorrect: This is not the appropriate advice.
C Incorrect: This is not the appropriate advice.
D Correct: The drug must be stopped and the client should see his prescriber as soon as possible, as these may be manifestations of a blood dyscrasia.