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More than 2,500 barbiturates have been synthesized. At the height of their popularity, about 50 were marketed for human use.
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The first war in which wide-scale use of anesthetics occurred was the Civil War, and 80% of all wounds were in the extremities.
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The word drug comes from the Dutch word droog (meaning "dry"). For centuries, most drugs came from dried plants, hence the name.
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The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.
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Many medications that are used to treat infertility are injected subcutaneously. This is easy to do using the anterior abdomen as the site of injection but avoiding the area directly around the belly button.
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