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Aspirin is the most widely used drug in the world. It has even been recognized as such by the Guinness Book of World Records.
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Disorders that may affect pharmacodynamics include genetic mutations, malnutrition, thyrotoxicosis, myasthenia gravis, Parkinson's disease, and certain forms of insulin-resistant diabetes mellitus.
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Addicts to opiates often avoid treatment because they are afraid of withdrawal. Though unpleasant, with proper management, withdrawal is rarely fatal and passes relatively quickly.
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In most cases, kidneys can recover from almost complete loss of function, such as in acute kidney (renal) failure.
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Individuals are never “cured” of addictions. Instead, they learn how to manage their disease to lead healthy, balanced lives.