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Cocaine was isolated in 1860 and first used as a local anesthetic in 1884. Its first clinical use was by Sigmund Freud to wean a patient from morphine addiction. The fictional character Sherlock Holmes was supposed to be addicted to cocaine by injection.
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In 1864, the first barbiturate (barbituric acid) was synthesized.
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The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.
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Approximately one in four people diagnosed with diabetes will develop foot problems. Of these, about one-third will require lower extremity amputation.
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According to the FDA, adverse drug events harmed or killed approximately 1,200,000 people in the United States in the year 2015.