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The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.
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The first oral chemotherapy drug for colon cancer was approved by FDA in 2001.
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Side effects from substance abuse include nausea, dehydration, reduced productivitiy, and dependence. Though these effects usually worsen over time, the constant need for the substance often overcomes rational thinking.
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Pope Sylvester II tried to introduce Arabic numbers into Europe between the years 999 and 1003, but their use did not catch on for a few more centuries, and Roman numerals continued to be the primary number system.
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People with high total cholesterol have about two times the risk for heart disease as people with ideal levels.