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Most childhood vaccines are 90–99% effective in preventing disease. Side effects are rarely serious.
Vaccines prevent between 2.5 and 4 million deaths every year.
Drug-induced pharmacodynamic effects manifested in older adults include drug-induced renal toxicity, which can be a major factor when these adults are experiencing other kidney problems.
A strange skin disease referred to as Morgellons has occurred in the southern United States and in California. Symptoms include slowly healing sores, joint pain, persistent fatigue, and a sensation of things crawling through the skin. Another symptom is strange-looking, threadlike extrusions coming out of the skin.
In most cases, kidneys can recover from almost complete loss of function, such as in acute kidney (renal) failure.

