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Sildenafil (Viagra®) has two actions that may be of consequence in patients with heart disease. It can lower the blood pressure, and it can interact with nitrates. It should never be used in patients who are taking nitrates.
The National Institutes of Health have supported research into acupuncture. This has shown that acupuncture significantly reduced pain associated with osteoarthritis of the knee, when used as a complement to conventional therapies.
Of the estimated 2 million heroin users in the United States, 600,000–800,000 are considered hardcore addicts. Heroin addiction is considered to be one of the hardest addictions to recover from.
Every 10 seconds, a person in the United States goes to the emergency room complaining of head pain. About 1.2 million visits are for acute migraine attacks.
Opium has influenced much of the world's most popular literature. The following authors were all opium users, of varying degrees: Lewis Carroll, Charles, Dickens, Arthur Conan Doyle, and Oscar Wilde.
![Cast of Isotelus rex, the largest known trilobite from the middle to upper Ordovician of North Ameri](https://biology-forums.com/gallery/47/medium_12359_29_04_12_6_05_29.jpeg)
![This lithograph by Currier and Ives gives an erroneous impression of the “battle.” Major Robert Ande](https://biology-forums.com/gallery/47/medium_376021_22_08_15_1_40_21_223431218.jpeg)