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The heart is located in the center of the chest, with part of it tipped slightly so that it taps against the left side of the chest.
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The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.
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Disorders that may affect pharmacodynamics include genetic mutations, malnutrition, thyrotoxicosis, myasthenia gravis, Parkinson's disease, and certain forms of insulin-resistant diabetes mellitus.
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Approximately one in four people diagnosed with diabetes will develop foot problems. Of these, about one-third will require lower extremity amputation.
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In 1864, the first barbiturate (barbituric acid) was synthesized.